Charles Murphy
Charles Murphy may refer to:
- Charles Murphy (1880–1958), Irish politician more commonly referred to as Cathal Ó Murchadha
- Charles Murphy (architect) (1890–1985), Chicago based architect of C.F. Murphy Associates, later Murphy/Jahn Inc.
- Charles Murphy (Canadian politician) (1862–1935), Canadian politician who represented Russell in the Canadian House of Commons, 1908–1925
- Charles Francis Murphy (1858–1924), American political figure who was leader of Tammany Hall, 1902–1924
- Charlie Murphy (born 1959), American writer, actor, and stand-up comedian
- Charles S. Murphy, White House Counsel during the Truman Administration, 1951–1953
- Charles Terrence Murphy (politician) (1926–2008), Canadian politician who represented Sault Ste. Marie in the Canadian House of Commons, 1968–1972
- Charles Minthorn Murphy (1870–1950), aka "Mile-a-Minute" Murphy, American cyclist
- Charles Murphy (architect) (1890–1985), American architect based in Chicago, Illinois
- Charles A. Murphy (born 1966), Massachusetts Representative from the 21st District
- Stretch Murphy, Charles "Stretch" Murphy (1907–1992), All-American basketball player at Purdue University
- Charles Murphy (baseball) (died 1931), baseball executive and sportswriter
- Charlie Murphy (artist), artist based in London, UK